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LEUKOTRIENES
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DeCS
Descriptor
English
:
Leukotrienes
Descriptor
Spanish
:
Leucotrienos
Descriptor
Portuguese
:
Leucotrienos
Tree Number:
D10.251.355.255.100.450
D10.251.355.310.166.887
D23.469.050.175.450
Definition
English
:
A
family
of biologically active compounds derived from
arachidonic acid
by oxidative
metabolism
through the 5-lipoxygenase pathway. They participate in host defense reactions and pathophysiological conditions such as immediate
hypersensitivity
and
inflammation
. They have potent actions on many essential organs and systems, including the cardiovascular, pulmonary, and
central nervous system
as well as the
gastrointestinal tract
and the
immune system.
Indexing Annotation
English
:
eicosanoids
; GEN or unspecified; prefer specifics; /biosyn /physiol permitted
Entry Combination - descr/qualif
English
:
Leukotrienes
/
antagonists & inhibitors
use
Leukotriene Antagonists
See Related
English
:
Receptors, Leukotriene
History Note
English
:
89
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
28158
Unique Identifier:
D015289
Occurrence in VHL
:
Similar:
DeCS