Search on: LFA-1 
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Descriptor English:   Lymphocyte Function-Associated Antigen-1 
Descriptor Spanish:   Antígeno-1 Asociado a Función de Linfocito 
Descriptor Portuguese:   Antígeno-1 Associado à Função Linfocitária 
Synonyms English:   Antigen-1, Lymphocyte Function-Associated
Integrin alphaLbeta2
LFA-1
Leukocyte Function Associated Antigen-1
Lymphocyte Function Associated Antigen 1
alphaLbeta2, Integrin  
Tree Number:   D12.776.395.550.200.074.937
D12.776.395.550.200.625.550
D12.776.543.550.200.093.937
D12.776.543.550.200.625.550
D12.776.543.750.705.408.600.400
D12.776.543.750.705.877.550
D23.050.301.350.074.400
D23.050.301.350.625.550
Definition English:   An integrin heterodimer widely expressed on cells of hematopoietic origin. CD11A ANTIGEN comprises the alpha chain and the CD18 antigen (CD18 ANTIGENS) the beta chain. Lymphocyte function-associated antigen-1 is a major receptor of T-CELLS; B-CELLS; and GRANULOCYTES. It mediates the leukocyte adhesion reactions underlying cytolytic conjugate formation, helper T-cell interactions, and antibody-dependent killing by NATURAL KILLER CELLS and granulocytes. Intracellular adhesion molecule-1 has been defined as a ligand for lymphocyte function-associated antigen-1. 
History Note English:   1991 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PD pharmacology
PH physiology PO poisoning
RE radiation effects TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   29009 
Unique Identifier:   D016169 

Occurrence in VHL:
 

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