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KININOGENS
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DeCS
Descriptor
English
:
Kininogens
Descriptor
Spanish
:
Quininógenos
Descriptor
Portuguese
:
Cininogênios
Synonyms
English
:
Cystatins, Kininogen
Kininogen
Kininogen Cystatins
Prekinins
Prokinins
T Kininogen
T-Kininogen
Thiostatin
Tree Number:
D12.644.276.812.654
D12.776.124.125.635
D12.776.467.812.654
D12.776.811.420
D23.119.630
D23.469.050.375.425
D23.529.812.654
Definition
English
:
Endogenous
peptides
present in most
body fluids
. Certain
enzymes
convert them to active
KININS
which are involved in
inflammation
, blood clotting, complement reactions, etc.
Kininogens
belong to the cystatin superfamily. They are
cysteine proteinase inhibitors
. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by
plasma kallikrein
to produce
BRADYKININ
. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by
tissue
kallikrein to produce
KALLIDIN.
Indexing Annotation
English
:
cysteine
proteinase inhib; /drug eff /physiol permitted
Pharmacological Action:
Cysteine Proteinase Inhibitors
History Note
English
:
74(72)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
28118
Unique Identifier:
D007704
Occurrence in VHL
:
Similar:
DeCS