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KARYOPHERIN-BETA
Descriptors Found:
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DeCS
Descriptor
English
:
beta Karyopherins
Descriptor
Spanish
:
beta Carioferinas
Descriptor
Portuguese
:
beta Carioferinas
Synonyms
English
:
Importin beta
Importin-beta
Importins, beta
Kap95 protein
Karyopherin beta
Karyopherin beta Subunit
Karyopherin-beta
Karyopherin-beta Subunit
Karyopherins, beta
beta Importins
nuclear protein, p92
p92 nuclear protein
Tree Number:
D12.776.157.530.750.500.249
D12.776.543.585.750.500.249
D12.776.660.502.500
Definition
English
:
Nucleocytoplasmic transport molecules that bind to
ALPHA KARYOPHERINS
in the
CYTOSOL
and are involved in transport of molecules through the
NUCLEAR PORE
COMPLEX. Once inside the
CELL NUCLEUS
beta karyopherins
interact with
RAN GTP-BINDING PROTEIN
and dissociate from
alpha karyopherins
.
Beta karyopherins
bound to
RAN GTP-BINDING PROTEIN
are then re-transported to the
cytoplasm
where
hydrolysis
of the GTP of
RAN GTP-BINDING PROTEIN
causes release of karyopherin beta.
History Note
English
:
2002; use BETA KARYOPHERINS (NM) 1995-2001; for IMPORTIN-BETA use KARYOPHERINS (NM) 1995-2001
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
36193
Unique Identifier:
D028961
Occurrence in VHL
:
Similar:
DeCS