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DeCS
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Descriptor English:
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Amiloride
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Descriptor Spanish:
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Amilorida
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Descriptor Portuguese:
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Amilorida
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Synonyms English:
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Amidal
Amiduret Trom
Amiloberag
Amiloride Hydrochloride
Amiloride Hydrochloride, Anhydrous
Anhydrous Amiloride Hydrochloride
Hydrochloride, Amiloride
Hydrochloride, Anhydrous Amiloride
Kaluril
Midamor
Midoride
Modamide
Trom, Amiduret
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Tree Number:
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D03.383.679.149
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Definition English:
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A pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride is used in conjunction with DIURETICS to spare POTASSIUM loss. (From Gilman et al., Goodman and Gilman's The Pharmacological Basis of Therapeutics, 9th ed, p705) |
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Pharmacological Action:
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Diuretics
Acid Sensing Ion Channel Blockers
Epithelial Sodium Channel Blockers
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History Note English:
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86(72); was see under PYRAZINES 1975-85, was Prov 1972-74
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Allowable Qualifiers English:
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Record Number:
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588
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Unique Identifier:
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D000584
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Occurrence in VHL:
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Similar:
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DeCS
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