Search on:
IMMUNOPHILINS
Descriptors Found:
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DeCS
Descriptor
English
:
Immunophilins
Descriptor
Spanish
:
Inmunofilinas
Descriptor
Portuguese
:
Imunofilinas
Synonyms
English
:
Neurophilin
Neurophilins
Tree Number:
D08.811.399.325.500.400
D12.776.543.750.705.400
D12.776.827.275
Definition
English
:
Members of a
family
of highly conserved
proteins
which are all cis-trans peptidyl-prolyl
isomerases
(
PEPTIDYLPROLYL ISOMERASE
). They bind the immunosuppressant drugs
CYCLOSPORINE
;
TACROLIMUS
and
SIROLIMUS
. They possess rotamase activity, which is inhibited by the immunosuppressant drugs that bind to them.
Indexing Annotation
English
:
don't confuse X ref NEUROPHILINS with
NEUROPILINS
History Note
English
:
2004(1999); for NEUROPHILIN use VASCULAR ENDOTHELIAL GROWTH FACTOR (NM) 1997-2003
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33828
Unique Identifier:
D020104
Occurrence in VHL
:
Similar:
DeCS