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DeCS
Descriptor
English
:
Interleukin-12
Descriptor
Spanish
:
Interleucina-12
Descriptor
Portuguese
:
Interleucina-12
Synonyms
English
:
Cytotoxic Lymphocyte Maturation Factor
Edodekin Alfa
IL 12
IL-12
IL-12 p70
IL12
Interleukin 12
Interleukin 12 p70
Interleukin-12 p70
Natural Killer Cell Stimulatory Factor
Tree Number:
D12.644.276.374.465.512
D12.776.467.374.465.512
D23.529.374.465.512
Definition
English
:
A heterodimeric cytokine that plays a role in innate and adaptive immune responses.
Interleukin-12
is a 70 kDa protein that is composed of covalently linked 40 kDa and 35 kDa subunits. It is produced by
DENDRITIC CELLS
;
MACROPHAGES
and a variety of other immune cells and plays a role in the stimulation of
INTERFERON-GAMMA
production by
T-LYMPHOCYTES
and NATURAL KILLER CELLS.
Pharmacological Action:
Adjuvants, Immunologic
Angiogenesis Inhibitors
See Related
English
:
Immunity, Cellular
Ustekinumab
History Note
English
:
1995 (1991)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
32173
Unique Identifier:
D018664
Occurrence in VHL
:
Similar:
DeCS