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DeCS
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Descriptor English:
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Hypoglycins
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Descriptor Spanish:
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Hipoglicinas
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Descriptor Portuguese:
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Hipoglicinas
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Tree Number:
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D02.455.426.392.368.533.450
D23.946.412
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Definition English:
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Methylene cyclopropyl alanine and congeners isolated from the unripe edible fruit of the AKEE plant (BLIGHIA SAPIDA). Hypoglycin B is the gamma-glutamyl congener of hypoglycin A. They are very toxic and teratogenic, causing a syndrome called Jamaican vomiting sickness that includes a fall in blood glucose due to the interference of FATTY ACIDS and LEUCINE metabolism which leads to VOMITING, liver damage, CONVULSIONS and DEATH. |
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Indexing Annotation English:
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Jamaican vomiting sickness : coordinate HYPOGLYCINS /pois (IM) with PLANT POISONING (IM)
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Pharmacological Action:
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Poisons
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History Note English:
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91(77); was see under CYCLOPROPANES 1977-90
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Allowable Qualifiers English:
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Record Number:
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7183
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Unique Identifier:
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D007005
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Occurrence in VHL:
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Similar:
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DeCS
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