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GENISTEIN
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DeCS
Descriptor
English
:
Genistein
Descriptor
Spanish
:
Genisteína
Descriptor
Portuguese
:
Genisteína
Synonyms
English
:
Genestein
Tree Number:
D03.383.663.283.266.450.400.375
D03.633.100.150.266.450.400.375
Definition
English
:
An isoflavonoid derived from soy products. It inhibits PROTEIN-TYROSINE KINASE and topoisomerase-II (
DNA TOPOISOMERASES
, TYPE II); activity and is used as an antineoplastic and antitumor agent. Experimentally, it has been shown to induce
G2 PHASE
arrest in human and murine cell lines and inhibits PROTEIN-TYROSINE KINASE.
Pharmacological Action:
Anticarcinogenic Agents
Protein Kinase Inhibitors
Phytoestrogens
History Note
English
:
98; use GENISTEIN (NM) 1980-97
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
33414
Unique Identifier:
D019833
Occurrence in VHL
:
Similar:
DeCS