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G-CSF
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DeCS
Descriptor
English
:
Granulocyte Colony-Stimulating Factor
Descriptor
Spanish
:
Factor Estimulante de Colonias de Granulocitos
Descriptor
Portuguese
:
Fator Estimulador de Colônias de Granulócitos
Synonyms
English
:
G-CSF
Tree Number:
D12.644.276.374.410.240.350
D12.776.395.240.200
D12.776.467.374.410.240.350
D23.529.374.410.240.350
Definition
English
:
A glycoprotein of MW 25 kDa containing internal disulfide bonds. It induces the
survival
, proliferation, and differentiation of neutrophilic
granulocyte precursor cells
and functionally activates mature blood
neutrophils
. Among the
family
of
colony-stimulating factors
, G-CSF is the most potent inducer of terminal differentiation to
granulocytes
and
macrophages
of leukemic myeloid cell lines.
See Related
English
:
Receptors, Granulocyte Colony-Stimulating Factor
History Note
English
:
91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
28968
Unique Identifier:
D016179
Occurrence in VHL
:
Similar:
DeCS