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DeCS
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Descriptor English:
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Phenytoin
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Descriptor Spanish:
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Fenitoína
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Descriptor Portuguese:
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Fenitoína
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Synonyms English:
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5,5-Diphenylhydantoin
5,5-diphenylimidazolidine-2,4-dione
Antisacer
Difenin
Dihydan
Dilantin
Diphenylhydantoin
Diphenylhydantoinate, Sodium
Epamin
Epanutin
Fenitoin
Hydantol
Phenytoin Sodium
Sodium Diphenylhydantoinate
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Tree Number:
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D03.383.129.308.432.555.730
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Definition English:
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An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs. |
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Pharmacological Action:
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Anticonvulsants
Voltage-Gated Sodium Channel Blockers
Cytochrome P-450 CYP1A2 Inducers
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History Note English:
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78; was DIPHENYLHYDANTOIN 1963-77
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Allowable Qualifiers English:
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Record Number:
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10867
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Unique Identifier:
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D010672
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Occurrence in VHL:
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Similar:
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DeCS
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