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Descriptor English:   Immunoglobulin Fab Fragments 
Descriptor Spanish:   Fragmentos Fab de Inmunoglobulinas 
Descriptor Portuguese:   Fragmentos Fab das Imunoglobulinas 
Synonyms English:   Fab Fragment Immunoglobulins
Fab Fragment, Immunoglobulin
Fab Fragments
Fab Fragments, Immunoglobulin
Fab Immunoglobulin Fragments
Fragment Immunoglobulins, Fab
Ig Fab Fragments
Immunoglobulin Fab Fragment
Immunoglobulin Fragments, Fab
Immunoglobulins, Fab
Immunoglobulins, Fab Fragment  
Tree Number:   D12.644.541.500.650
Definition English:   Univalent antigen-binding fragments composed of one entire IMMUNOGLOBULIN LIGHT CHAIN and the amino terminal end of one of the IMMUNOGLOBULIN HEAVY CHAINS from the hinge region, linked to each other by disulfide bonds. Fab contains the IMMUNOGLOBULIN VARIABLE REGIONS, which are part of the antigen-binding site, and the first IMMUNOGLOBULIN CONSTANT REGIONS. This fragment can be obtained by digestion of immunoglobulins with the proteolytic enzyme PAPAIN. 
Pharmacological Action:   Immunologic Factors
History Note English:   2006 (1973) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PD pharmacology
PH physiology PO poisoning
RE radiation effects TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22214 
Unique Identifier:   D007140 

Occurrence in VHL: