Descriptors Found: 1
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Descriptor English:   F-Box-WD Repeat-Containing Protein 7 
Descriptor Spanish:   Proteína 7 que Contiene Repeticiones F-Box-WD 
Descriptor Portuguese:   Proteína 7 com Repetições F-Box-WD 
Synonyms English:   F Box WD Repeat Containing Protein 7
F Box and WD 40 Domain Containing Protein 7
F-Box and WD-40 Domain-Containing Protein 7
FBXW7 Protein  
Tree Number:   D08.811.464.938.750.750.750
Definition English:   A component of SCF(FBW7) UBIQUITIN LIGASE that contains an F-box motif and multiple WD REPEATS. It recognizes and binds phosphorylated signals in several proteins involved in CELL PROLIFERATION and targets them to the SCF complex for UBIQUITINATION. Targets include CYCLIN E; PROTO-ONCOGENE PROTEINS C-JUN; PROTO-ONCOGENE PROTEINS C-MYC; and JNK MITOGEN-ACTIVATED PROTEIN KINASES. 
History Note English:   2018 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   57012 
Unique Identifier:   D000073979 

Occurrence in VHL: