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EXENATIDE
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DeCS
Descriptor
English
:
Exenatide
Descriptor
Spanish
:
Exenatida
Descriptor
Portuguese
:
Exenatida
Synonyms
English
:
AC 2993
AC 2993 LAR
Bydureon
Byetta
Ex4 Peptide
Exendin 4
Exendin-4
ITCA 650
Peptide, Ex4
Tree Number:
D12.644.187
D20.888.300
D23.946.833.300
Definition
English
:
A synthetic form of exendin-4, a 39-amino acid peptide isolated from the venom of the Gila monster lizard (
Heloderma suspectum
).
Exenatide
increases
CYCLIC AMP
levels in pancreatic
acinar cells
and acts as a
GLUCAGON-LIKE PEPTIDE-1 RECEPTOR
(GLP-1) agonist and incretin mimetic, enhancing
insulin secretion
in response to increased
glucose
levels; it also suppresses inappropriate
glucagon
secretion and slows
gastric emptying
. It is used an anti-diabetic and anti-obesity agent.
Pharmacological Action:
Hypoglycemic Agents
Anti-Obesity Agents
Incretins
History Note
English
:
2019 (1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
57573
Unique Identifier:
D000077270
Occurrence in VHL
:
Similar:
DeCS