Search on: EFLORNITHINE 
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Descriptor English:   Eflornithine 
Descriptor Spanish:   Eflornitina 
Descriptor Portuguese:   Eflornitina 
Synonyms English:   DL alpha Difluoromethylornithine
DL-alpha-Difluoromethylornithine
Difluoromethylornithine
Eflornithine Hydrochloride
Eflornithine Monohydrochloride, Monohydrate
MDL 71,782 A
MDL-71,782 A
MDL71,782 A
Ornidyl
Ornithine, alpha-Difluoromethyl
RMI 71782
Vaniqa
alpha Difluoromethyl Ornithine
alpha Difluoromethylornithine
alpha-Difluoromethyl Ornithine
alpha-Difluoromethylornithine  
Tree Number:   D12.125.068.665.340
D12.125.095.765.340
Definition English:   An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway. 
Pharmacological Action:   Antineoplastic Agents
Trypanocidal Agents
Ornithine Decarboxylase Inhibitors
 
History Note English:   1991; use ALPHA-DIFLUOROMETHYLORNITHINE 1987-1990 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification EC economics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   29232 
Unique Identifier:   D000518 

Occurrence in VHL: 		 

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