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DeCS
Descriptor
English
:
Donepezil
Descriptor
Spanish
:
Donepezilo
Descriptor
Portuguese
:
Donepezila
Synonyms
English
:
1-Benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methylpiperidine hydrochloride
Aricept
Donepezil Hydrochloride
Donepezilium Oxalate Trihydrate
E 2020
E-2020
E2020
Eranz
Tree Number:
D02.455.426.559.847.486.487.280
D03.383.621.238
D04.615.486.487.280
Definition
English
:
An indan and piperidine derivative that acts as a selective and reversible inhibitor of
ACETYLCHOLINESTERASE
.
Donepezil
is highly selective for the
central nervous system
and is used in the management of mild to moderate
DEMENTIA
in
ALZHEIMER DISEASE.
Pharmacological Action:
Cholinesterase Inhibitors
Nootropic Agents
History Note
English
:
2019 (1992)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
57568
Unique Identifier:
D000077265
Occurrence in VHL
:
Similar:
DeCS