Search on: CALPAIN 
Descriptors Found: 1
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Descriptor English:   Calpain 
Descriptor Spanish:   Calpaína 
Descriptor Portuguese:   Calpaína 
Synonyms English:   Ca2+ Activated Protease
Ca2+-Activated Protease
Calcium Activated Neutral Protease
Calcium Activated Neutral Proteinase
Calcium Activated Protease
Calcium Dependent Neutral Protease
Calcium Dependent Neutral Proteinase
Calcium-Activated Neutral Protease
Calcium-Activated Neutral Proteinase
Calcium-Activated Protease
Calcium-Dependent Neutral Protease
Calcium-Dependent Neutral Proteinase
Calpain I
Calpain II
Desminase
Neutral Protease, Calcium-Activated
Neutral Protease, Calcium-Dependent
Neutral Proteinase, Calcium-Activated
Neutral Proteinase, Calcium-Dependent
Protease, Ca2+-Activated
Protease, Calcium-Activated
Protease, Calcium-Activated Neutral
Protease, Calcium-Dependent Neutral
Proteinase, Calcium-Activated Neutral
Proteinase, Calcium-Dependent Neutral  
Tree Number:   D08.811.277.656.262.500.120
D08.811.277.656.300.200.120
Definition English:   Cysteine proteinase found in many tissues. Hydrolyzes a variety of endogenous proteins including NEUROPEPTIDES; CYTOSKELETAL PROTEINS; proteins from SMOOTH MUSCLE; CARDIAC MUSCLE; liver; platelets; and erythrocytes. Two subclasses having high and low calcium sensitivity are known. Removes Z-discs and M-lines from myofibrils. Activates phosphorylase kinase and cyclic nucleotide-independent protein kinase. This enzyme was formerly listed as EC 3.4.22.4. 
Indexing Annotation English:   /biosyn /physiol permitted
History Note English:   86 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   23227 
Unique Identifier:   D002154 

Occurrence in VHL: 		 

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