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Descriptor English:   Tumor Necrosis Factor-alpha 
Descriptor Spanish:   Factor de Necrosis Tumoral alfa 
Descriptor Portuguese:   Fator de Necrose Tumoral alfa 
Synonyms English:   Cachectin
Cachectin Tumor Necrosis Factor
Cachectin-Tumor Necrosis Factor
TNF Superfamily, Member 2
TNF-alpha
TNFalpha
Tumor Necrosis Factor
Tumor Necrosis Factor Ligand Superfamily Member 2
Tumor Necrosis Factor alpha  
Tree Number:   D12.644.276.374.500.800
D12.644.276.374.750.626
D12.776.124.900
D12.776.395.930
D12.776.467.374.500.800
D12.776.467.374.750.626
D23.529.374.500.800
D23.529.374.750.626
Definition English:   Serum glycoprotein produced by activated MACROPHAGES and other mammalian MONONUCLEAR LEUKOCYTES. It has necrotizing activity against tumor cell lines and increases ability to reject tumor transplants. Also known as TNF-alpha, it is only 30% homologous to TNF-beta (LYMPHOTOXIN), but they share TNF RECEPTORS. 
See Related English:   Adalimumab
Certolizumab Pegol
Infliximab
 
History Note English:   2005(1988) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   29591 
Unique Identifier:   D014409 

Occurrence in VHL:
 

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