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CYP11B2
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DeCS
Descriptor
English
:
Cytochrome P-450 CYP11B2
Descriptor
Spanish
:
Citocromo P-450 CYP11B2
Descriptor
Portuguese
:
Citocromo P-450 CYP11B2
Synonyms
English
:
Aldosterone Synthase
Aldosterone Synthase Cytochrome P-450
Aldosynthase
CYP 11B2
CYP11B2
Cytochrome P 450 CYP11B2
Cytochrome P 450c11AS
Cytochrome P-450c11AS
Cytochrome P450 11B2
Cytochrome P450Aldo
P450c11AS
Steroid 18 Hydroxylase
Steroid 18-Hydroxylase
Tree Number:
D08.244.453.484.500
D08.244.453.915.050
D08.811.682.690.708.170.425.500
D08.811.682.690.708.170.915.050
D12.776.422.220.453.484.500
D12.776.422.220.453.915.050
Definition
English
:
A mitochondrial
cytochrome
P450 enzyme that catalyzes the 18-hydroxylation of
steroids
in the presence of molecular
oxygen
and NADPH-specific
flavoprotein
. This enzyme, encoded by CYP11B2 gene, is important in the conversion of
CORTICOSTERONE
to
18-hydroxycorticosterone
and the subsequent conversion to
ALDOSTERONE.
Indexing Annotation
English
:
/antag: coordinate with
CYTOCHROME P-450 ENZYME INHIBITORS
History Note
English
:
2015 (1979)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33013
Unique Identifier:
D019405
Occurrence in VHL
:
Similar:
DeCS