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CYP11B1
Descriptors Found:
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DeCS
Descriptor
English
:
Steroid 11-beta-Hydroxylase
Descriptor
Spanish
:
Esteroide 11-beta-Hidroxilasa
Descriptor
Portuguese
:
Esteroide 11-beta-Hidroxilase
Synonyms
English
:
11 beta Hydroxylase
11 beta-Hydroxylase
CYP 11B1
CYP11B1
Cytochrome P 450 CYP11B1
Cytochrome P-450 CYP11B1
Cytochrome P-450(11 beta)
Cytochrome P450 11B1
Steroid 11 Hydroxylase
Steroid 11 beta Hydroxylase
Steroid 11 beta Monooxygenase
Steroid 11-Hydroxylase
Steroid 11-beta-Monooxygenase
Steroid-11-Hydroxylase
Tree Number:
D08.244.453.484.750
D08.244.453.915.750
D08.811.682.690.708.170.425.750
D08.811.682.690.708.170.915.750
D12.776.422.220.453.484.750
D12.776.422.220.453.915.750
Definition
English
:
A mitochondrial
cytochrome
P450 enzyme that catalyzes the 11-beta-hydroxylation of
steroids
in the presence of molecular
oxygen
and
NADPH-FERRIHEMOPROTEIN REDUCTASE
. This enzyme, encoded by CYP11B1 gene, is important in the synthesis of
CORTICOSTERONE
and
HYDROCORTISONE
. Defects in CYP11B1 cause congenital adrenal
hyperplasia
(ADRENAL
HYPERPLASIA
, CONGENITAL).
Entry Combination - descr/qualif
English
:
Steroid 11-beta-Hydroxylase
/
deficiency
use
Adrenal Hyperplasia, Congenital
See Related
English
:
Adrenal Hyperplasia, Congenital
History Note
English
:
2003 (1978)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23463
Unique Identifier:
D013252
Occurrence in VHL
:
Similar:
DeCS