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DeCS
Descriptor
English
:
Cytochrome P-450 CYP2B1
Descriptor
Spanish
:
Citocromo P-450 CYP2B1
Descriptor
Portuguese
:
Citocromo P-450 CYP2B1
Synonyms
English
:
7 Benzyloxyresorufin O Dealkylase
7 Pentylresorufin O Depentylase
7-Benzyloxyresorufin O-Dealkylase
7-Pentylresorufin O-Depentylase
BROD
Benzyloxyresorufin O Dealkylase
Benzyloxyresorufin O-Dealkylase
CYP 2B1
CYP2B1
Cytochrome P 450 CYP2B1
Cytochrome P450 2B1
O-Dealkylase, Pentoxyresorufin
PROD
Pentoxyresorufin O Dealkylase
Pentoxyresorufin O-Dealkylase
Tree Number:
D08.244.453.005.550
D08.244.453.491.313
D08.811.682.690.708.170.010.550
D08.811.682.690.708.170.450.313
D12.776.422.220.453.010.550
D12.776.422.220.453.491.313
Definition
English
:
A major
cytochrome
P-450 enzyme which is inducible by
PHENOBARBITAL
in both the LIVER and SMALL
INTESTINE
. It is active in the
metabolism
of compounds like pentoxyresorufin,
TESTOSTERONE
, and
ANDROSTENEDIONE
. This enzyme, encoded by CYP2B1 gene, also mediates the activation of
CYCLOPHOSPHAMIDE
and
IFOSFAMIDE
to
MUTAGENS.
Indexing Annotation
English
:
do not confuse with other
cytochrome
P-450 CYP's
History Note
English
:
97; was PENTOXYRESORUFIN O-DEALKYLASE (NM) 1985-96
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
33010
Unique Identifier:
D019362
Occurrence in VHL
:
Similar:
DeCS