Search on:
ANISTREPLASE
Descriptors Found:
1
Displaying:
1 .. 1
1 / 1
DeCS
Descriptor
English
:
Anistreplase
Descriptor
Spanish
:
Anistreplasa
Descriptor
Portuguese
:
Anistreplase
Synonyms
English
:
APSAC
Anisoylated Plasminogen-Streptokinase Activator Complex
BRL 26921
BRL-26921
BRL26921
Eminase
Iminase
Tree Number:
D08.811.277.656.300.760.635.075
D08.811.277.656.300.775.075
D08.811.277.656.959.350.635.075
D12.776.124.125.662.537.075
Definition
English
:
An acylated inactive complex of
streptokinase
and human lysine-plasminogen. After injection, the acyl group is slowly hydrolyzed, producing an activator that converts
plasminogen
to plasmin, thereby initiating
fibrinolysis
. Its
half-life
is about 90 minutes compared to 5 minutes for TPA; (
TISSUE PLASMINOGEN ACTIVATOR
); 16 minutes for
UROKINASE-TYPE PLASMINOGEN ACTIVATOR
and 23 minutes for
STREPTOKINASE
. If treatment is initiated within 3 hours of onset of symptoms for acute
myocardial infarction
, the drug preserves myocardial
tissue
and left
ventricular function
and increases coronary
artery
patency. Bleeding complications are
similar
to other thrombolytic agents.
Pharmacological Action:
Fibrinolytic Agents
History Note
English
:
91
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
28860
Unique Identifier:
D016255
Occurrence in VHL
:
Similar:
DeCS