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DeCS
Descriptor
English
:
Aripiprazole
Descriptor
Spanish
:
Aripiprazol
Descriptor
Portuguese
:
Aripiprazol
Synonyms
English
:
7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
Abilify
Aripiprazol
OPC 14597
OPC-14597
Tree Number:
D03.383.606.170
D03.633.100.810.835.122
Definition
English
:
A
piperazine
and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of
SEROTONIN
RECEPTOR, 5-HT1A and
DOPAMINE
D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of
SEROTONIN
RECEPTOR, 5-HT2A. It is used for the treatment of
SCHIZOPHRENIA
and
BIPOLAR DISORDER
, and as an adjunct therapy for the treatment of
depression.
Pharmacological Action:
Antidepressive Agents
Antipsychotic Agents
Dopamine Agonists
Serotonin 5-HT1 Receptor Agonists
Serotonin 5-HT2 Receptor Antagonists
Dopamine D2 Receptor Antagonists
History Note
English
:
2016 (1995)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
55922
Unique Identifier:
D000068180
Occurrence in VHL
:
Similar:
DeCS