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4,4-DIFLUORO-N-((1S)-3-(EXO-3-(3-ISOPROPYL-5-METHYL-4H-1,2,4-TRIAZOL-4-YL)-8-AZABICYCLO(3.2.1)OCT-8-YL)-1-PHENYLPROPYL)CYCLOHEXANECARBOXAMIDE
Descriptors Found:
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DeCS
Descriptor
English
:
Maraviroc
Descriptor
Spanish
:
Maraviroc
Descriptor
Portuguese
:
Maraviroc
Synonyms
English
:
4,4-Difluoro-N-((1S)-3-(exo-3-(3-isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo(3.2.1)oct-8-yl)-1-phenylpropyl)cyclohexanecarboxamide
Selzentry
UK 427,857
UK 427857
UK-427,857
UK-427857
UK427,857
UK427857
Tree Number:
D02.455.426.392.368.367.726
D03.383.129.799.682
Definition
English
:
A cyclohexane and triazole derivative that acts as an antagonist of the CCR5 RECEPTOR. It prevents infection by HIV-1 virus strains which use CCR5 as a co-receptor for
membrane fusion
and cellular entry.
Pharmacological Action:
HIV Fusion Inhibitors
CCR5 Receptor Antagonists
History Note
English
:
2019 (2005)
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
AI
antagonists & inhibitors
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
EC
economics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
57699
Unique Identifier:
D000077592
Occurrence in VHL
:
Similar:
DeCS