|
1 / 1
|
DeCS
|
|
 |
|
Descriptor Inglés:
|
|
PR-SET Domains
|
|
Descriptor Español:
|
|
Dominios PR-SET
|
|
Descriptor Portugués:
|
|
Domínios PR-SET
|
|
Sinónimos Inglés:
|
|
Domain, PR
Domain, PR-SET
Domain, SET
Domains, PR
Domains, PR-SET
Domains, SET
PR Domain
PR Domains
PR SET Domains
PR-SET Domain
SET Domain
SET Domains
|
|
Categoría:
|
|
G02.111.570.820.709.275.750.477
|
|
Definición Inglés:
|
|
Highly conserved protein domains of approximately 130 to 140 amino acids. The SET domain was first identified in the Drosophila proteins (S)u(var)3-9, (E)nhancer-of-zeste and (T)rithorax and occurs in other proteins with a variety of functions, including histone-lysine N-methyltransferases. Structurally, it consists of BETA-SHEETS interspersed among loops and turns that result in an "L" shape. The most conserved motifs are a stretch at the C-terminal that contains a strictly conserved tyrosine residue and an adjacent loop that the C-terminal segment passes through to form a "knot". These motifs and especially the tyrosine residue are essential for S-ADENOSYLMETHIONINE binding and catalysis. The PR domain has high homology to the catalytic region of the SET domain and occurs at the N-terminal of PRDM proteins such as PRDM1 PROTEIN. |
|
Nota Histórica Inglés:
|
|
2018
|
|
Calificadores Permitidos Inglés:
|
|
|
|
Número del Registro:
|
|
57255
|
|
Identificador Único:
|
|
D000074463
|
Ocurrencia en la BVS:
|
|
|
Similar:
|
|
DeCS
|
|