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DeCS
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Descriptor Inglés:
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Pre-B-Cell Leukemia Transcription Factor 1
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Descriptor Español:
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Factor de Transcripción 1 de la Leucemia de Células Pre-B
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Descriptor Portugués:
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Fator de Transcrição 1 de Leucemia de Células Pré-B
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Sinónimos Inglés:
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Homeobox Protein, PBX1
PBX1 Homeobox Protein
Pre B Cell Leukemia Homeobox 1 Protein
Pre B Cell Leukemia Transcription Factor 1
Pre-B-Cell Leukemia Homeobox 1 Protein
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Categoría:
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D12.776.260.400.836
D12.776.624.664.700.163
D12.776.930.712
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Definición Inglés:
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A TALE-type homeodomain protein and transcription factor that binds the DNA sequence 5'-ATCAATCAA-3'. It forms a heterodimer with MEIS1 TRANSCRIPTION FACTOR and functions as a transcriptional activator of HOMEOBOX PROTEIN NKX-2.5 and ELONGIN A, and as a transcriptional repressor of CDKN2B PROTEIN, in the regulation of developmental and morphogenetic processes such as spleen and limb development. Chromosome translocations involving the PBX1 and TCF3 genes occur in cases of pre-B-cell ACUTE LYMPHOID LEUKEMIA. |
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Nota Histórica Inglés:
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2018
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Calificadores Permitidos Inglés:
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Número del Registro:
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57110
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Identificador Único:
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D000075062
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Ocurrencia en la BVS:
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Similar:
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DeCS
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