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DeCS
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Descriptor Inglés:
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High-Temperature Requirement A Serine Peptidase 2
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Descriptor Español:
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Serina Peptidasa A2 que Requiere Temperaturas Altas
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Descriptor Portugués:
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Serina Peptidase 2 de Requerimento de Alta Temperatura A
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Sinónimos Inglés:
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HTRA2, Serine Protease
High Temperature Requirement A Serine Peptidase 2
HtrA Serine Peptidase 2
HtrA2 Protease
Omi Serine Protease
Omi, Serine Protease
Protease HTRA2, Serine
Protease Omi, Serine
Protease, HtrA2
Protease, Omi Serine
Serine Protease HTRA2
Serine Protease Omi
Serine Protease, Omi
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Categoría:
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D08.811.277.656.300.760.431
D08.811.277.656.959.350.431
D12.644.360.075.429
D12.776.476.075.429
D12.776.575.656
D12.776.637.625
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Definición Inglés:
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A serine peptidase that contains a C-terminal PDZ domain. It localizes to the mitochondrial membrane and intermembrane space, translocating to the cytoplasm following APOPTOSIS stimuli, such as UV irradiation; it promotes cell death by binding to and inhibiting INHIBITOR OF APOPTOSIS PROTEINS, resulting in an increase in activity of CASPASES. Mutations in the HTRA2 gene are associated with Type 13 PARKINSON DISEASE. |
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Relacionados Inglés:
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PDZ Domains
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Nota Histórica Inglés:
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2018 (2000)
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Calificadores Permitidos Inglés:
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Número del Registro:
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57008
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Identificador Único:
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D000074923
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Ocurrencia en la BVS:
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Similar:
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DeCS
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