Expresión de búsqueda: MFN=57002 
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Descriptor Inglés:   SAM Domain and HD Domain-Containing Protein 1 
Descriptor Español:   Proteína 1 que Contiene Dominios SAM y HD 
Descriptor Portugués:   Proteína 1 com Domínio SAM e Domínio HD 
Sinónimos Inglés:   SAM Domain and HD Domain Containing Protein 1
SAMHD1 Deoxynucleoside Triphosphate Triphosphohydrolase
SAMHD1 Protein
SAMHD1 dNTPase  
Categoría:   D08.811.277.040.725
D08.811.277.352.700.843
Definición Inglés:   A host restriction triphosphorylhydrolase and dNTPase that contains an N-terminal STERILE ALPHA MOTIF and central, conserved ASPARTATE and HISTIDINE (HD) domain. It acts on single-stranded RNA, yielding deoxynucleosides and triphosphate, and functions in anti-viral defense through its dNTPase activity, reducing cellular dNTP levels below what is required for retroviral reverse transcription in DENDRITIC CELLS and MYELOID CELLS. It also has RIBONUCLEASE activity which blocks early replication of retroviruses such as HIV-1. Mutations in the SAMHD1 gene are associated with type 5 Aicardi-Goutieres syndrome (AGS5) and type 2 chilblain LUPUS (CHBL2). 
Nota Histórica Inglés:   2018 
Calificadores Permitidos Inglés:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Número del Registro:   57002 
Identificador Único:   D000076106 

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