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DeCS
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Descriptor Inglés:
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Mechanistic Target of Rapamycin Complex 2
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Descriptor Español:
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Diana Mecanicista del Complejo 2 de la Rapamicina
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Descriptor Portugués:
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Alvo Mecanístico do Complexo 2 de Rapamicina
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Sinónimos Inglés:
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Complex 2, TOR
MTORC-2
TOR Complex 2
TORC2
Target of Rapamycin Complex 2
mTORC2
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Categoría:
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D05.500.356
D08.811.913.696.620.682.700.931.750
D12.776.476.925.750
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Definición Inglés:
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A multiprotein complex consisting of mTOR KINASE; MLST8 PROTEIN; rapamycin-insensitive companion of mTOR protein (RICTOR PROTEIN); and PRR5 (proline-rich protein 5). Like mTORC1, it also regulates cell growth and proliferation in response to growth factors but may not be as sensitive to nutrient availability and is insensitive to SIROLIMUS. In contrast to mTORC1, it can regulate the ACTIN CYTOSKELETON through RHO GTPASES to promote the formation of STRESS FIBERS. The mTORC2 complex also plays a critical role in AKT1 PROTEIN KINASE phosphorylation and activation. |
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Nota Histórica Inglés:
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2018 (2013)
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Calificadores Permitidos Inglés:
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Número del Registro:
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56985
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Identificador Único:
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D000076225
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Ocurrencia en la BVS:
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Similar:
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DeCS
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