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MFN=56982
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DeCS
Descriptor
Inglés
:
Mechanistic Target of Rapamycin Complex 1
Descriptor
Español
:
Diana Mecanicista del Complejo 1 de la Rapamicina
Descriptor
Portugués
:
Alvo Mecanístico do Complexo 1 de Rapamicina
Sinónimos
Inglés
:
Complex, mTORC1
TOR Complex 1
TORC1
Target of Rapamycin Complex 1
mTORC1
mTORC1 Complex
Categoría:
D05.500.337
D08.811.913.696.620.682.700.931.500
D12.776.476.925.500
Definición
Inglés
:
An evolutionarily conserved multiprotein complex that functions as a cellular energy sensor and regulator of protein synthesis for cell
growth
and proliferation. It consists of
TOR SERINE-THREONINE KINASES
;
REGULATORY-ASSOCIATED PROTEIN OF MTOR
(RAPTOR); MLST8 PROTEIN; and AKT1 substrate 1 protein. The activity of the complex is regulated by
SIROLIMUS
;
INSULIN
;
GROWTH
FACTORS;
PHOSPHATIDIC ACIDS
; some
amino acids
or amino acid derivatives, and
OXIDATIVE STRESS.
Nota Histórica
Inglés
:
2018 (2013)
Calificadores Permitidos
Inglés
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Número del Registro:
56982
Identificador Único:
D000076222
Ocurrencia en la BVS
:
Similar:
DeCS