Descriptors Found: 1
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Descriptor English:   von Willebrand Factor 
Descriptor Spanish:   Factor de von Willebrand 
Descriptor Portuguese:   Fator de von Willebrand 
Synonyms English:   Factor VIII Related Antigen
Factor VIII-Related Antigen
Factor VIIIR Ag
Factor VIIIR RCo
Factor VIIIR-Ag
Factor VIIIR-RCo
Plasma Factor VIII Complex
Ristocetin Cofactor
Ristocetin Willebrand Factor
Ristocetin-Willebrand Factor
von Willebrand Protein  
Tree Number:   D12.776.124.125.920
Definition English:   A high-molecular-weight plasma protein, produced by endothelial cells and megakaryocytes, that is part of the factor VIII/von Willebrand factor complex. The von Willebrand factor has receptors for collagen, platelets, and ristocetin activity as well as the immunologically distinct antigenic determinants. It functions in adhesion of platelets to collagen and hemostatic plug formation. The prolonged bleeding time in VON WILLEBRAND DISEASES is due to the deficiency of this factor. 
Indexing Annotation English:   / defic = VON WILLEBRAND DISEASE or specific type of Von Willebrand Disease
See Related English:   Coagulants
Weibel-Palade Bodies
von Willebrand Disease, Type 1
von Willebrand Disease, Type 2
von Willebrand Disease, Type 3
von Willebrand Diseases
History Note English:   86(76); was see under BLOOD COAGULATION FACTORS 1976-85; FACTOR VIII RELATED ANTIGEN, previously in the Supplementary Chemical File, was mapped to both FACTOR VIII & ANTIGENS 1977-89 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22305 
Unique Identifier:   D014841 

Occurrence in VHL: