Descriptors Found: 1
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Descriptor English:   Signal Transduction 
Descriptor Spanish:   Transducción de Señal 
Descriptor Portuguese:   Transdução de Sinais 
Synonyms English:   Cell Signaling
Pathway, Signal
Pathway, Signal Transduction
Pathways, Signal
Pathways, Signal Transduction
Receptor Mediated Signal Transduction
Receptor-Mediated Signal Transduction
Receptor-Mediated Signal Transductions
Signal Pathway
Signal Pathways
Signal Transduction Pathway
Signal Transduction Pathways
Signal Transduction System
Signal Transduction Systems
Signal Transduction, Receptor-Mediated
Signal Transductions
Signal Transductions, Receptor-Mediated
System, Signal Transduction
Systems, Signal Transduction
Transduction, Signal
Transductions, Signal  
Tree Number:   G02.111.820
Definition English:   The intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation. Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. Those coupled to membrane depolarization or intracellular release of calcium include the receptor-mediated activation of cytotoxic functions in granulocytes and the synaptic potentiation of protein kinase activation. Some signal transduction pathways may be part of larger signal transduction pathways; for example, protein kinase activation is part of the platelet activation signal pathway. 
See Related English:   Ion Channels
History Note English:   89 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   23827 
Unique Identifier:   D015398 

Occurrence in VHL: