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Descriptor English:   Platelet Glycoprotein GPIIb-IIIa Complex 
Descriptor Spanish:   Complejo GPIIb-IIIa de Glicoproteína Plaquetaria 
Descriptor Portuguese:   Complexo Glicoproteico GPIIb-IIIa de Plaquetas 
Synonyms English:   GPIIb IIIa Receptors
GPIIb-IIIa Receptors
Glycoproteins IIb IIIa
Glycoproteins IIb-IIIa
Integrin alpha IIb beta 3
Integrin alpha-IIb beta-3
Integrin alphaIIbbeta3
Platelet Glycoprotein GPIIb IIIa Complex
Receptors, GPIIb-IIIa
alphaIIbbeta3, Integrin
beta-3, Integrin alpha-IIb  
Tree Number:   D12.776.395.550.625.785
Definition English:   Platelet membrane glycoprotein complex important for platelet adhesion and aggregation. It is an integrin complex containing INTEGRIN ALPHAIIB and INTEGRIN BETA3 which recognizes the arginine-glycine-aspartic acid (RGD) sequence present on several adhesive proteins. As such, it is a receptor for FIBRINOGEN; VON WILLEBRAND FACTOR; FIBRONECTIN; VITRONECTIN; and THROMBOSPONDINS. A deficiency of GPIIb-IIIa results in GLANZMANN THROMBASTHENIA. 
Entry Combination - descr/qualif English:   Platelet Glycoprotein GPIIb-IIIa Complex/deficiency use Thrombasthenia
See Related English:   Thrombasthenia
History Note English:   1996(1987); use INTEGRIN ALPHAIIBBETA3 (NM) 1992-1995 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   32647 
Unique Identifier:   D019039 

Occurrence in VHL: