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Descriptor English:   Neurofibrillary Tangles 
Descriptor Spanish:   Ovillos Neurofibrilares 
Descriptor Portuguese:   Emaranhados Neurofibrilares 
Synonyms English:   Neurofibrillary Tangle
Tangle, Neurofibrillary
Tangles, Neurofibrillary  
Tree Number:   A08.675.609.520
Definition English:   Abnormal structures located in various parts of the brain and composed of dense arrays of paired helical filaments (neurofilaments and microtubules). These double helical stacks of transverse subunits are twisted into left-handed ribbon-like filaments that likely incorporate the following proteins: (1) the intermediate filaments: medium- and high-molecular-weight neurofilaments; (2) the microtubule-associated proteins map-2 and tau; (3) actin; and (4) UBIQUITINS. As one of the hallmarks of ALZHEIMER DISEASE, the neurofibrillary tangles eventually occupy the whole of the cytoplasm in certain classes of cell in the neocortex, hippocampus, brain stem, and diencephalon. The number of these tangles, as seen in post mortem histology, correlates with the degree of dementia during life. Some studies suggest that tangle antigens leak into the systemic circulation both in the course of normal aging and in cases of Alzheimer disease. 
See Related English:   Diffuse Neurofibrillary Tangles with Calcification
Neurofilament Proteins
History Note English:   92 
Allowable Qualifiers English:  
CH chemistry CL classification
DE drug effects EN enzymology
GE genetics IM immunology
ME metabolism MI microbiology
PS parasitology PA pathology
PH physiology RE radiation effects
TR transplantation UL ultrastructure
VI virology  
Record Number:   29933 
Unique Identifier:   D016874 

Occurrence in VHL: