Descriptors Found: 1
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Descriptor English:   MAP Kinase Signaling System 
Descriptor Spanish:   Sistema de Señalización de MAP Quinasas 
Descriptor Portuguese:   Sistema de Sinalização das MAP Quinases 
Synonyms English:   Cascade, MAP Kinase
ERK Pathway
ERK Pathways
ERK Signal Tranduction Pathway
ERK1 2 Pathway
ERK1 and ERK2 Pathway
ERK1-2 Pathway
ERK1-2 Pathways
JNK Pathway
JNK Pathways
JNK Signaling Pathway
JNK Signaling Pathways
Kinase Cascade, MAP
Kinase Pathway, p38
Kinase Pathways, p38
MAP Kinase Cascade
MAP Kinase Cascades
MAP Kinase Module
MAP Kinase Modules
MAP Kinase Signaling Cascades
MAP Kinase Signaling Pathways
MEK ERK Pathway
MEK-ERK Pathway
MEK-ERK Pathways
Module, MAP Kinase
Pathway, ERK
Pathway, ERK1-2
Pathway, JNK
Pathway, JNK Signaling
Pathway, MEK-ERK
Pathway, p38 Kinase
Pathways, ERK
Pathways, ERK1-2
Pathways, JNK
Pathways, JNK Signaling
Pathways, MEK-ERK
Pathways, p38 Kinase
Signaling Pathway, JNK
Signaling Pathways, JNK
p38 Kinase Pathway
p38 Kinase Pathways
p38 Kinase Signaling Pathway  
Tree Number:   G02.111.820.560
Definition English:   An intracellular signaling system involving the MAP kinase cascades (three-membered protein kinase cascades). Various upstream activators, which act in response to extracellular stimuli, trigger the cascades by activating the first member of a cascade, MAP KINASE KINASE KINASES; (MAPKKKs). Activated MAPKKKs phosphorylate MITOGEN-ACTIVATED PROTEIN KINASE KINASES which in turn phosphorylate the MITOGEN-ACTIVATED PROTEIN KINASES; (MAPKs). The MAPKs then act on various downstream targets to affect gene expression. In mammals, there are several distinct MAP kinase pathways including the ERK (extracellular signal-regulated kinase) pathway, the SAPK/JNK (stress-activated protein kinase/c-jun kinase) pathway, and the p38 kinase pathway. There is some sharing of components among the pathways depending on which stimulus originates activation of the cascade. 
See Related English:   MAP Kinase Kinase Kinases
Mitogen-Activated Protein Kinase Kinases
Mitogen-Activated Protein Kinases
History Note English:   2000 
Allowable Qualifiers English:  
DE drug effects GE genetics
IM immunology PH physiology
RE radiation effects  
Record Number:   34468 
Unique Identifier:   D020935 

Occurrence in VHL: