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Descriptor English:   JNK Mitogen-Activated Protein Kinases 
Descriptor Spanish:   Proteínas Quinasas JNK Activadas por Mitógenos 
Descriptor Portuguese:   Proteínas Quinases JNK Ativadas por Mitógeno 
Synonyms English:   Amino-Terminal Kinase, c-jun
JNK Mitogen Activated Protein Kinases
N-Terminal Kinase, c-jun
c jun Amino Terminal Kinase
c jun N Terminal Kinase
c-jun Amino-Terminal Kinase
c-jun N-Terminal Kinase
jun NH2 Terminal Kinase
jun NH2 Terminal Kinases
jun-NH2-Terminal Kinase
jun-NH2-Terminal Kinases  
Tree Number:   D08.811.913.696.620.682.700.567.374
Definition English:   A subgroup of mitogen-activated protein kinases that activate TRANSCRIPTION FACTOR AP-1 via the phosphorylation of C-JUN PROTEINS. They are components of intracellular signaling pathways that regulate CELL PROLIFERATION; APOPTOSIS; and CELL DIFFERENTIATION. 
Indexing Annotation English:   note specifics
History Note English:   2005 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   38731 
Unique Identifier:   D048031 

Occurrence in VHL: