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Descriptor English:   Interferons 
Descriptor Spanish:   Interferones 
Descriptor Portuguese:   Interferons 
Synonyms English:   Interferon  
Tree Number:   D12.644.276.374.440
Definition English:   Proteins secreted by vertebrate cells in response to a wide variety of inducers. They confer resistance against many different viruses, inhibit proliferation of normal and malignant cells, impede multiplication of intracellular parasites, enhance macrophage and granulocyte phagocytosis, augment natural killer cell activity, and show several other immunomodulatory functions. 
Indexing Annotation English:   "stimulators" or "inducers" = INTERFERON INDUCERS
Pharmacological Action:   Antineoplastic Agents
Antiviral Agents
See Related English:   Receptors, Interferon
History Note English:   83; was INTERFERON 1963-82 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   29469 
Unique Identifier:   D007372 

Occurrence in VHL: