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INSULIN
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DeCS
Descriptor
English
:
Insulin
Descriptor
Spanish
:
Insulina
Descriptor
Portuguese
:
Insulina
Synonyms
English
:
Chain, Insulin B
Iletin
Insulin A Chain
Insulin B Chain
Insulin, Regular
Insulin, Sodium
Insulin, Soluble
Novolin
Regular Insulin
Sodium Insulin
Soluble Insulin
Tree Number:
D06.472.699.587.200.500.625
D12.644.548.586.200.500.625
Definition
English
:
A 51-amino acid pancreatic hormone that plays a major role in the regulation of
glucose
metabolism
, directly by suppressing endogenous
glucose
production (
GLYCOGENOLYSIS
;
GLUCONEOGENESIS
) and indirectly by suppressing
GLUCAGON
secretion and
LIPOLYSIS
. Native
insulin
is a globular protein comprised of a zinc-coordinated hexamer. Each
insulin
monomer containing two chains, A (21 residues) and B (30 residues), linked by two disulfide bonds.
Insulin
is used as a drug to
control
insulin-dependent
diabetes mellitus
(
DIABETES MELLITUS
, TYPE 1).
Indexing Annotation
English
:
/blood
: consider also HYPERINSULINEMIA (excessively high blood
insulin
levels) but do not confuse with
HYPERINSULINISM
(excessive secretion of
insulin
by
pancreas
);
/immunology
: consider also
INSULIN ANTIBODIES
; precursor =
PROINSULIN
;
INSULIN INFUSION SYSTEMS
is available
Pharmacological Action:
Hypoglycemic Agents
Entry Combination - descr/qualif
English
:
Insulin
/
antagonists & inhibitors
use
Insulin Antagonists
See Related
English
:
Hyperinsulinism
Nonsuppressible Insulin-Like Activity
Proinsulin
Receptor, Insulin
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AG
agonists
AA
analogs & derivatives
AN
analysis
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
DF
deficiency
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UR
urine
Record Number:
7500
Unique Identifier:
D007328
Occurrence in VHL
:
Similar:
DeCS