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Descriptor English:   Glucose-6-Phosphate Isomerase 
Descriptor Spanish:   Glucosa-6-Fosfato Isomerasa 
Descriptor Portuguese:   Glucose-6-Fosfato Isomerase 
Synonyms English:   Autocrine Motility Factor
Factor, Autocrine Motility
Glucose 6 Phosphate Isomerase
Glucosephosphate Isomerase
Isomerase, Glucose 6 Phosphate
Isomerase, Glucose-6-Phosphate
Isomerase, Glucosephosphate
Isomerase, Phosphoglucose
Isomerase, Phosphohexose
Motility Factor, Autocrine
Phosphoglucose Isomerase
Phosphohexose Isomerase
Tumor Autocrine Motility Factor
Tumor Cell Autocrine Motility Factor
Tumor-Cell Autocrine Motility Factor  
Tree Number:   D08.811.399.475.200.350
Definition English:   An aldose-ketose isomerase that catalyzes the reversible interconversion of glucose 6-phosphate and fructose 6-phosphate. In prokaryotic and eukaryotic organisms it plays an essential role in glycolytic and gluconeogenic pathways. In mammalian systems the enzyme is found in the cytoplasm and as a secreted protein. This secreted form of glucose-6-phosphate isomerase has been referred to as autocrine motility factor or neuroleukin, and acts as a cytokine which binds to the AUTOCRINE MOTILITY FACTOR RECEPTOR. Deficiency of the enzyme in humans is an autosomal recessive trait, which results in CONGENITAL NONSPHEROCYTIC HEMOLYTIC ANEMIA. 
Entry Combination - descr/qualif English:   Glucose-6-Phosphate Isomerase/deficiency use Anemia, Hemolytic, Congenital Nonspherocytic
History Note English:   1998(1965) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   6101 
Unique Identifier:   D005956 

Occurrence in VHL: