Search on: GIANT CELLS 
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Descriptor English:   Giant Cells 
Descriptor Spanish:   CÚlulas Gigantes 
Descriptor Portuguese:   CÚlulas Gigantes 
Synonyms English:   Cell, Giant
Cell, Multinucleated Giant
Cells, Giant
Cells, Multinucleated Giant
Giant Cell
Giant Cell, Multinucleated
Giant Cells, Multinucleated
Multinucleated Giant Cell
Multinucleated Giant Cells
Polykaryocyte
Polykaryocytes
Syncytia
Syncytium  
Tree Number:   A11.500
Definition English:   Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus. 
History Note English:   90 
Allowable Qualifiers English:  
CH chemistry CL classification
CY cytology DE drug effects
EN enzymology IM immunology
ME metabolism MI microbiology
PS parasitology PA pathology
PH physiology RE radiation effects
TR transplantation UL ultrastructure
VI virology  
Record Number:   24694 
Unique Identifier:   D015726 

Occurrence in VHL:
 

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