Descriptors Found: 1
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Descriptor English:   Epoprostenol 
Descriptor Spanish:   Epoprostenol 
Descriptor Portuguese:   Epoprostenol 
Synonyms English:   Epoprostanol
Epoprostenol Sodium
Epoprostenol Sodium Salt, (5Z,9alpha,11alpha,13E,15S)-Isomer
Prostaglandin I(2)
Prostaglandin I2
Tree Number:   D10.251.355.255.550.550.500
Definition English:   A prostaglandin that is a powerful vasodilator and inhibits platelet aggregation. It is biosynthesized enzymatically from PROSTAGLANDIN ENDOPEROXIDES in human vascular tissue. The sodium salt has been also used to treat primary pulmonary hypertension (HYPERTENSION, PULMONARY). 
Pharmacological Action:   Antihypertensive Agents
Platelet Aggregation Inhibitors
History Note English:   1991 (1978); use PROSTAGLANDINS X 1978-1990; for PROSTACYCLIN use PROSTACYCLINS 1978-1993; for PROSTAGLANDIN I2 use PROSTAGLANDINS I2 1982-1993; for PROSTAGLANDIN X use PROSTAGLANDINS X 1991-1993 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AA analogs & derivatives
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UR urine  
Record Number:   29280 
Unique Identifier:   D011464 

Occurrence in VHL: