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Descriptor English:   E2F Transcription Factors 
Descriptor Spanish:   Factores de Transcripción E2F 
Descriptor Portuguese:   Fatores de Transcrição E2F 
Synonyms English:   E2F Proteins
E2F, Transcription Factor
Transcription Factor E2F
Transcription Factors, E2F  
Tree Number:   D12.776.930.211
Definition English:   A family of basic helix-loop-helix transcription factors that control expression of a variety of GENES involved in CELL CYCLE regulation. E2F transcription factors typically form heterodimeric complexes with TRANSCRIPTION FACTOR DP1 or transcription factor DP2, and they have N-terminal DNA binding and dimerization domains. E2F transcription factors can act as mediators of transcriptional repression or transcriptional activation. 
History Note English:   2006(1991) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   51180 
Unique Identifier:   D050684 

Occurrence in VHL: