Descriptors Found: 1
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Descriptor English:   Core Binding Factor alpha Subunits 
Descriptor Spanish:   Subunidades alfa del Factor de Unión al Sitio Principal 
Descriptor Portuguese:   Subunidades alfa de Fatores de Ligação ao Core 
Synonyms English:   Acute Myeloid Leukemia Proteins
Core Binding Factor alpha Proteins
PEBP2A Transcription Factors
Polyomavirus Enhancer A Binding Protein 2
Polyomavirus Enhancer Binding Protein 2, Alpha Subunit
Runt Domain Factor
Runx Proteins
Transcription Factors, PEBP2A  
Tree Number:   D12.776.930.155.200
Definition English:   A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding domain known as the runt domain. They can act as both activators and repressors of expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression. 
History Note English:   2006(1987) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Record Number:   51175 
Unique Identifier:   D050657 

Occurrence in VHL: