Search on: COMPLEMENT MEMBRANE ATTACK COMPLEX 
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Descriptor English:   Complement Membrane Attack Complex 
Descriptor Spanish:   Complejo de Ataque a Membrana del Sistema Complemento 
Descriptor Portuguese:   Complexo de Ataque Membrana do Sistema Complemento 
Synonyms English:   C 5b-9
C5b 8 poly C9
C5b-8-poly-C9
C5b-9
Complement Complex C5b 9
Complement Complex C5b-9
Complement Complex, Terminal
Complex, Terminal Complement
Cytolytic Terminal Complement Complex
Membrane Attack Complex
Terminal Complement Complex  
Tree Number:   D12.776.124.486.274.930
Definition English:   A product of COMPLEMENT ACTIVATION cascade, regardless of the pathways, that forms transmembrane channels causing disruption of the target CELL MEMBRANE and cell lysis. It is formed by the sequential assembly of terminal complement components (COMPLEMENT C5B; COMPLEMENT C6; COMPLEMENT C7; COMPLEMENT C8; and COMPLEMENT C9) into the target membrane. The resultant C5b-8-poly-C9 is the "membrane attack complex" or MAC. 
Pharmacological Action:   Immunologic Factors
 
History Note English:   90 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   24583 
Unique Identifier:   D015938 

Occurrence in VHL:
 

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