Search on: COMPLEMENT C3 
Descriptors Found: 1
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Descriptor English:   Complement C3 
Descriptor Spanish:   Complemento C3 
Descriptor Portuguese:   Complemento C3 
Synonyms English:   C3 Complement
C3 Precursor
C3 Precursor, Complement
C3, Complement
Complement 3
Complement C3 Precursor
Complement Component 3
Complement, C3
Component 3, Complement
Precursor Complement 3
Precursor, C3
Precursor, Complement C3
Precursor-Complement 3
Pro C3
Pro Complement 3
Pro-Complement 3  
Tree Number:   D12.776.124.050.140
Definition English:   A glycoprotein that is central in both the classical and the alternative pathway of COMPLEMENT ACTIVATION. C3 can be cleaved into COMPLEMENT C3A and COMPLEMENT C3B, spontaneously at low level or by C3 CONVERTASE at high level. The smaller fragment C3a is an ANAPHYLATOXIN and mediator of local inflammatory process. The larger fragment C3b binds with C3 convertase to form C5 convertase. 
Pharmacological Action:   Immunologic Factors
History Note English:   2006 (1975) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AG agonists AN analysis
AI antagonists & inhibitors BI biosynthesis
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   22135 
Unique Identifier:   D003176 

Occurrence in VHL: