Descriptors Found: 1
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Descriptor English:   Amyotrophic Lateral Sclerosis 
Descriptor Spanish:   Esclerosis Amiotrófica Lateral 
Descriptor Portuguese:   Esclerose Amiotrófica Lateral 
Synonyms English:   ALS - Amyotrophic Lateral Sclerosis
ALS Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis Parkinsonism Dementia Complex 1
Amyotrophic Lateral Sclerosis With Dementia
Amyotrophic Lateral Sclerosis, Guam Form
Amyotrophic Lateral Sclerosis, Parkinsonism Dementia Complex of Guam
Amyotrophic Lateral Sclerosis, Parkinsonism-Dementia Complex of Guam
Amyotrophic Lateral Sclerosis-Parkinsonism-Dementia Complex 1
Charcot Disease
Dementia With Amyotrophic Lateral Sclerosis
Disease, Guam
Disease, Lou-Gehrigs
Gehrig Disease
Gehrig's Disease
Gehrigs Disease
Guam Disease
Guam Form of Amyotrophic Lateral Sclerosis
Lou Gehrig Disease
Lou Gehrig's Disease
Lou-Gehrigs Disease
Motor Neuron Disease, Amyotrophic Lateral Sclerosis
Sclerosis, Amyotrophic Lateral  
Tree Number:   C10.228.854.139
Definition English:   A degenerative disorder affecting upper MOTOR NEURONS in the brain and lower motor neurons in the brain stem and SPINAL CORD. Disease onset is usually after the age of 50 and the process is usually fatal within 3 to 6 years. Clinical manifestations include progressive weakness, atrophy, FASCICULATION, hyperreflexia, DYSARTHRIA, dysphagia, and eventual paralysis of respiratory function. Pathologic features include the replacement of motor neurons with fibrous ASTROCYTES and atrophy of anterior SPINAL NERVE ROOTS and corticospinal tracts. (From Adams et al., Principles of Neurology, 6th ed, pp1089-94) 
Allowable Qualifiers English:  
BL blood CF cerebrospinal fluid
CI chemically induced CL classification
CO complications CN congenital
DI diagnosis DG diagnostic imaging
DH diet therapy DT drug therapy
EC economics EM embryology
EN enzymology EP epidemiology
EH ethnology ET etiology
GE genetics HI history
IM immunology ME metabolism
MI microbiology MO mortality
NU nursing PS parasitology
PA pathology PP physiopathology
PC prevention & control PX psychology
RT radiotherapy RH rehabilitation
SU surgery TH therapy
UR urine VE veterinary
VI virology  
Record Number:   704 
Unique Identifier:   D000690 

Occurrence in VHL: