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DeCS
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Descriptor English:
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Nedd4 Ubiquitin Protein Ligases
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Descriptor Spanish:
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Ubiquitina-Proteína Ligasas Nedd4
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Descriptor Portuguese:
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Ubiquitina-Proteína Ligases Nedd4
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Synonyms English:
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Nedd4 Proteins
Neuronal Precursor Cell Expressed Developmentally Down Regulated 4 Ligase
Neuronal Precursor Cell-Expressed Developmentally Down-Regulated 4 Ligase
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Tree Number:
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D05.500.199.500
D08.811.464.938.750.257
D12.776.543.990.493.500
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Definition English:
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E3 ubiquitin ligases that consist of four WW DOMAINS. They accept UBIQUITIN from E2 UBIQUITIN-CONJUGATING ENZYME as a thioester via their C-terminal HECT domains and transfer it specifically to the 63rd LYSINE residue (Lys-63) of target proteins. NEDD4 targets include many proteins and receptors with important functions for cell growth and homeostasis such as VEGFR-2; FGFR1 TYROSINE KINASE; and ERBB-4 RECEPTOR. They play a critical role in the internalization of these receptors, their degradation by LYSOSOMES, and also function as part of the ESCRT complex in VIRUS RELEASE. |
History Note English:
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2018 (1996)
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Allowable Qualifiers English:
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Record Number:
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56981
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Unique Identifier:
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D000075702
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Occurrence in VHL:
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Similar:
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DeCS
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