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DeCS
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Descriptor English:
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Lovastatin
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Descriptor Spanish:
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Lovastatina
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Descriptor Portuguese:
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Lovastatina
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Synonyms English:
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1 alpha-Isomer Lovastatin
6 Methylcompactin
6-Methylcompactin
Lovastatin, (1 alpha(S*))-Isomer
Lovastatin, 1 alpha Isomer
Lovastatin, 1 alpha-Isomer
MK 803
MK-803
MK803
Mevacor
Mevinolin
Monacolin K
alpha-Isomer Lovastatin, 1
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Tree Number:
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D02.455.426.559.847.638.400
D04.615.638.400
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Definition English:
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A fungal metabolite isolated from cultures of Aspergillus terreus. The compound is a potent anticholesteremic agent. It inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase (HYDROXYMETHYLGLUTARYL COA REDUCTASES), which is the rate-limiting enzyme in cholesterol biosynthesis. It also stimulates the production of low-density lipoprotein receptors in the liver. |
Pharmacological Action:
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Anticholesteremic Agents
Hydroxymethylglutaryl-CoA Reductase Inhibitors
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History Note English:
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88; for MONACOLIN K use LOVASTATIN (NM) 1980-98
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Allowable Qualifiers English:
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Record Number:
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22932
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Unique Identifier:
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D008148
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Occurrence in VHL:
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Similar:
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DeCS
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